Assuntos
Diarreia/dietoterapia , Dieta , Medicina Baseada em Evidências , Medicina Tradicional , HumanosRESUMO
OBJECTIVE AND METHODS: Functional changes in the kidneys of healthy men with (FH+) (n = 15) and without (FH-) (n = 15) family history of primary arterial hypertension were examined during administration of low-dose exogenous angiotensin II (A2) (1 ng/kg per min) before and after acute (1 mg intravenous enalaprilat) and chronic (7 days oral enalapril, 30 mg/day) angiotensin-converting enzyme (ACE) inhibition. RESULTS: Before chronic ACE inhibition, A2 increased mean arterial blood pressure (FH+, 8.7 +/- 0.8 mmHg; FH-, 8.9 +/- 0.9 mmHg), plasma immunoreactive A2 (FH+, 21 +/- 2 pg/ml; FH-, 18 +/- 3 pg/ml) and plasma aldosterone (FH+, 64 +/- 7 pg/ml; FH-, 56 +/- 6 pg/ml) to a similar degree in both groups. Chronic ACE inhibition had no impact on A2 blood pressure, plasma A2, or plasma aldosterone effects. A2 significantly increased renal vascular resistance in both groups (FH+, 3956 +/- 462 dyne s cm(-5); FH-, 2219 +/- 550 dyne s cm(-5)), but the effect was more pronounced in FH+ (P = 0.02). Glomerular hemodynamics, estimated by a modified Gomez model, revealed increased afferent and efferent responsiveness to A2 in FH+ subjects. These differences disappeared after chronic ACE inhibition when total, afferent and efferent sensitivities to A2 were similar in both groups. CONCLUSIONS: Systemic blood pressure and plasma aldosterone responses to A2 were similar in men with or without a genetic disposition to primary arterial hypertension. However, our data demonstrate that men with a family history of hypertension have increased renovascular sensitivity to A2, and that chronic ACE inhibition normalizes their sensitivity.
Assuntos
Angiotensina II/administração & dosagem , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Predisposição Genética para Doença/genética , Hipertensão/tratamento farmacológico , Hipertensão/genética , Rim/efeitos dos fármacos , Vasoconstritores/administração & dosagem , Adolescente , Adulto , Aldosterona/sangue , Angiotensina II/metabolismo , Biomarcadores/sangue , Pressão Sanguínea/efeitos dos fármacos , Diástole/efeitos dos fármacos , Relação Dose-Resposta a Droga , Taxa de Filtração Glomerular/efeitos dos fármacos , Humanos , Rim/irrigação sanguínea , Rim/metabolismo , Masculino , Valores de Referência , Fluxo Sanguíneo Regional/efeitos dos fármacos , Renina/efeitos dos fármacos , Renina/metabolismo , Sístole/efeitos dos fármacos , Fatores de Tempo , Resultado do Tratamento , Resistência Vascular/efeitos dos fármacos , Vasoconstritores/metabolismoRESUMO
A study of serum-samples from immunised individuals showed that administration of yellow-fever and cholera vaccine, simultaneously or one to three weeks apart, reduced the vibriocidal and yellow-fever-virus-neutralising antibody titres (AU)
